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HMGCR: Description: 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] Organism: Homo sapiens: Synonym(s) b7z3y9, ldlcq3, q8n190 2021-03-06 · Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects renal ischemia/reperfusion activates the HMGCR gene via multiple stress-activated transcriptional and epigenetic pathways, contributing to renal cholesterol loading. Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary 2014-11-24 · Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides.

2021-04-06 · Hmgcr MGI Mouse Gene Detail - MGI:96159 - 3-hydroxy-3-methylglutaryl-Coenzyme A reductase. View mouse Hmgcr Chr13:96648967-96670936 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home. Blood lipid genetic scores, the HMGCR gene and cancer risk: A Mendelian randomization study.

Luskey (1987) determined that the human HMGCR gene has several transcriptional start sites that generate relatively short 5-prime UTRs of 73 to 105 nucleotides.

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All these results indicate that the change in the expression of the HMGCR protein during the cholesterol and lovastatin feeding is a result of sterol-mediated modulation of its degradation. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR Gene name. HMGCR : Synonyms.

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It is required during heart tube formation, molting regulation and primordial germ cell migration. [Date last reviewed: 2019-05-16] HMGCR Gene Record Summary; Interactions; Claims; HMGCR 3156 Druggable Genome. Alternate Names: 3156 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE HMGCR LDLCQ3 142910 5006 2012-09-18 · The gene encoding HMGCR uses alternative, mutually exclusive exon 1 sequences. This contributes to an increased complexity of HMGCR transcripts. Further studies are needed to investigate whether HMGCR splice variants identified in this study are physiologically functional. HMGCR_ENST00000511206 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, HMGCR_ENST00000511206 Genome Browser, HMGCR_ENST00000511206 References HMGCR_ENST00000511206 - Explore an overview of HMGCR_ENST00000511206, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

2467 individuals in the general population-based EpiHealth. study [13]. Using summary data from large GWASs for dia-. betes and related 113, 319711, E230029C05Rik, RIKEN cDNA E230029C05 gene, ncRNA, 4.37E-05 662, 15357, Hmgcr, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Target genes. AMPK. STATINER.
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Concordantly, the levels of HMGCS1-mRNA and -protein were diminished to 60% and 70% in ACBP-expressing HeLa cells, respectively.
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Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. The present work provides evidence to support the association of promoter DNA methylation status with the risk profile of CHD. Our data indicates that promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the p Search external sites for HMGCR Gene information about ENSG00000113161 / HMGCR - 3-hydroxy-3-methylglutaryl-CoA reductase We also investigated cancer risk for a SNP (rs12916) in the gene encoding hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the targeted enzyme in statin treatment.

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View mouse Hmgcr Chr13:96648967-96670936 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression.

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The human gene (HMGCR)has been 23 Sep 2019 Phikud Navakot (PN), nine selected herbal remedies from those components in NY, regulates HMGCR and LDLR genes leading to enhance 11 Jun 2019 reductase (HMGCR) is negatively associated with PCV2 infection in vitro and in vivo.

Ensembl ID: ENSMUSG00000021670: Name: Hmgcr: Description Symbol Description Category GIFtS GC id Score; 1: HMGCR: 3-Hydroxy-3-Methylglutaryl-CoA Reductase: Protein Coding: 47: GC05P075336: 47.16: 2: PRKAA2: Protein Kinase AMP-Activated Catalytic Subunit Alpha 2 Searching the mammalian genome databases with the protein sequence of human HMGCR revealed only a single HMGCR gene in all three genomes, i.e., only a single gene with a statistically significant similarity to the catalytic domain of HMGCR (TBLASTN E-score < 0.001). The human gene is localized at 5q13.3-q14.3 and the rodent homologs are found Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids. HMGCR protein and Hmgcr mRNA levels of DMSO-treated cells were defined as 1.